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甲基盐霉素作为鸡饲料添加剂在70mg/kg饲料的使用水平下不存在环境风险
来源: 发布时间:2018/12/5 发布人:admin
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   据欧盟食品安全局(EFSA)消息,近日,应欧盟委员会要求,欧盟动物饲料添加剂和产品(FEEDAP)研究小组就Monteban®G100(甲基盐霉素)作为鸡饲料添加剂的安全性和功效发表科学意见。

  经过评估,根据现有的数据,FEADP小组无法得出Monteban®G100作为鸡饲料添加剂的安全性结论也没有足够的信息来确定添加剂的功效。但Monteban®G100作为鸡饲料添加剂在70mg/kg饲料的使用水平下不存在环境风险。

  部分原文报道如下:

  The feed additive Monteban® G100, containing the active substance narasin, an ionophore anticoccidial, is intended to control coccidiosis in chickens for fattening at a dose of 60-70 mg/kg complete feed. Narasin is produced by fermentation. Limited data on the taxonomic identification of the production strain did not allow the proper identification of strain NRRL 8092 as Streptomyces aureofaciens. The FEEDAP Panel cannot conclude on the absence of genetic determinants for antimicrobial resistance in Streptomyces spp. under assessment. based on the available data set, the FEEDAP Panel cannot conclude on the safety of Monteban®G100 for chickens for fattening. The simultaneous use of Monteban® G100 and certain antibiotic drugs (e.g. tiamulin) is contraindicated. Narasin is not genotoxic. No indication of carcinogenicity or developmental toxicity was found at the doses tested in the mouse, rat and rabbit. The lowest no observed effect level (NOEL) identified in the oral toxicity studies was 0.5 mg/kg body weight (bw) per day for the neuropathy seen in a one﹜ear dog study. The acceptable daily intake (ADI) derived from this NOEL is 0.005 mg narasin/kg bw applying a uncertainty factor of 100. Monteban® G100 is safe for the consumer. Maximum residue limits (MRLs) of 50 μg narasin/kg for all wet tissues ensure consumer safety. Monteban®G100 is irritatant to the eyes but not to the skin. It has the potential to induce skin sensitisation. Inhalation exposure would pose a risk to persons handling the additive. Narasin, when used as a feed additive for chickens for fattening at 70 mg/kg feed, is not expected to pose a risk to the environment. The risk for sediment compartment cannot be assessed. The FEEDAP Panel cannot conclude on the efficacy of Monteban® at the minimum applied dose of 60 mg narasin/kg complete feed for chickens for fattening.

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